Born in Holland, Lotte trained at the Amsterdam Academy of Dramatic Arts. Her first professional role was the lead in the television drama series, MOES. Her first leading role in a feature film, LEFT, she played five different characters. The film was awarded a Silver Melies in Sweden.
In 2009, she earned a European Academy Award Best Actress nomination, for her performance in NOTHING PERSONAL opposite Stephen Rea. In addition, she was also chosen as one of Europe’s Shooting Stars and won the Best Actress Award at the International Film Festivals of Locarno and Marrakech, and nominated for the National Dutch Film Award, Golden Calf, for Best Actress. She also won the Best Actress Award at the Monte Carlo TV Film Festival for her work in Italian mini series THE QUEENS OF SWING.
In the highly acclaimed Showtime television series THE BORGIAS, Lotte played the ravishing mistress of the Pope as Giulia Farnese. She next starred in Mike Figgis’ psychological thriller, SUSPENSION OF DISBELIEF, and was nominated for the CinemaXXI Award.
Lotte starred in the highly successful film THE FAULT IN OUR STARS Lotte also stars in STARZ hit series OUTLANDER, in which she plays the sexy and mysterious witch Geillis Duncan.